Transcription Infidelity An Ubiquitous Biological process
- DNA transcription by RNApolII at genes
- 2 RNA are produced: canonical RNA and frameshifted RNA (deletion = gap) = mechanism of transcription infidelity
- These 2 RNA are translated into canonical protein and Transcription infidelity Protein (TIP)
- The major characteristic of the segment encoded after the frameshift is cationic (in red) and is immunoreactive
TI technology makes any protein the target of self-produced antibodies
Defining antibody isotype by selective TI