Transcription Infidelity An Ubiquitous Biological process

1. DNA transcription by RNApolII at genes
2. 2 RNA are produced: canonical RNA and frameshifted RNA (deletion = gap) = mechanism of transcription infidelity
3. These 2 RNA are translated into canonical protein and Transcription infidelity Protein (TIP)
4. The major characteristic of the segment encoded after the frameshift is cationic (in red) and is immunoreactive

The Transcription Infidelity Paradigm

TI technology makes any protein the target of self-produced antibodies

Defining antibody isotype by selective TI